What Is Suspension Stability

Suspension stability can be achieved in a variety of ways. ▪ Prevent coagulation through inter-particle repulsion (steric or electrostatic stabilisation) ▪ Slow down sedimentation by increasing the viscosity of continuous phase – Kinetic stability.

What is meant by suspension stability?

Suspension stability can be theoretically estimated prior to the beginning of the formulating process based on the solid phase particle size, liquid phase density, and viscosity. In order to prevent formation of the solid sediment, controlled flocculation of the suspended bismuth subnitrate particles is recommended.

Why is suspension stable?

Suspension Stability Increasing the zero-shear viscosity of the continuous phase of an emulsion or suspension is a popular method of increasing physical stability. Controlled stress measurements on high performance rheometers are a necessity for zero-shear viscosity testing.

How do you stabilize suspension?

Stabilizing a suspension There are various routes that can be undertaken to improve suspension stability – for example, stabilization can be achieved by: preventing coagulation through inter-particle repulsion. slowing down sedimentation by increasing the viscosity of the continuous phase.

What are the roles of suspending agents in suspension stability?

Suspending agents form film around particle and decrease interparticulate attraction. At rest the solution is sufficient viscous to prevent sedimentation and thus aggregation or caking of the particles. When agitation is applied the viscosity is reduced and provide good flow characteristic from the mouth of bottle.

Is suspension more stable than solution?

Finally, drugs in suspension are chemically more stable than in solution. This is particularly important with certain antibiotics and the pharmacist is often called on to prepare such a suspension just prior to the dispensing of the preparation.

What is a suspension agent?

: a substance (such as carrageenan, xanthan gum, or cellulose ether) that is added to fluids to promote particle suspension or dispersion and reduce sedimentation All these drinks can contain preservatives, and drinks other than juices can contain additives to colour, flavour and sweeten.

Is a suspension stable?

For larger particles gravity dominates if there is a significant density difference (∆ρ). Particle radius (a) will have a large bearing on suspension stability. To maintain stability through Brownian motion we need to prevent particles sticking when they collide.

How did you identify solution and suspension?

Explanation: Solutions are substances that are composed of several components but appear as a single indistinguishable state. Suspensions on the other hand are mixtures wherein the basic components could still be distinguished.

Which is desirable suspension?

Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015

Which is more stable colloid or suspension?

and Suspension is unstable. Colloid particles are also small but larger than true solution(1nm to 100nm) so they also mix and do not settle at the bottom. But in suspension the particles are quite large (larger than 100nm) so they do not mix and settle at the bottom so they are unstable.

What is a suspension drug?

A suspension is a liquid with small pieces of drug. The drug is not complete dissolved in the solution. Whenever you take a suspension, you should always shake (or stir) it so that you receive the right amount of drug every time you take it.

Is the instability condition of a suspension?

It is important to understand that suspensions are kinetically stable, but thermodynamically unstable, system. Physical stability is defined as the condition in which the particles remain uniformly distributed throughout the dispersion without any signs of sedimentation. It is difficult to achieve this condition.

How can drug stability be improved?

To more optimally exploit the potential of PM for targeted drug delivery, several physical (e.g. π-π stacking, stereocomplexation, hydrogen bonding, host-guest complexation and coordination interaction) and chemical (e.g. free radical polymerization, click chemistry, disulfide and hydrazone bonding) strategies have Jul 14, 2016

What are 3 types of suspension?

There are three basic types of suspension components: linkages, springs, and shock absorbers.

What is a suspension formulation?

Pharmaceutical suspensions are liquid dosage forms containing finely divided insoluble materials (the suspensoid) distributed somewhat uniformly throughout the suspending medium (suspending vehicle) in which the drug exhibits a minimum degree of solubility.

What are 5 examples of suspension?

Examples of Suspension

• Muddy water.
• Milk of magnesia.
• Sand particles suspended in water.
• Flour in water.
• Slaked lime for whitewashing.
• Paints in which dyes are suspended in turpentine oil.

What is the stability of true solution?

Properties	True solution	Colloids
Stability	Solution is stable as the solute particles do not settle down when left undisturbed.	Stable

How does particle size affect stability of suspension?

In terms of stability, particle size has a direct effect on the ease of maintenance of a uniform suspended phase. However, for larger particles, the effect of gravity becomes significant, especially if there is a sizeable difference in density between the dispersed and continuous phases.

How suspension improves drug stability?

There are some useful methods to improve the physical stability of a suspension, such as decreasing the salt concentration, addition of additives to regulate the osmolarity, as well as changes in excipient concentrations, unit operations in the process, origin and synthesis of the drug substance, polymorphic behavior

How does suspension appear?

An suspension is when you mix a liquid and a solid, where the solid does not dissolve in the liquid. If this appears then you have an suspension. The suspension will appear as small “grain” looking object floating in the solution.

Which agent is used for stability of suspension?

Xanthan gum in drug delivery applications XG is widely used as a suspending agent and stabilizer in suspension due to its safety properties in food and drug applications. Moreover, it is soluble in water and can provide sufficient viscosity in low concentration.

What is the major stability problem related to the suspension?

The main problem dealt with in this article is preventing the aggregation of particles in a suspension — extensive aggregation can lead to ‘caking’. This is the process in which almost all particles in the sediment become interconnected, making it impossible to resuspend.

What is suspension used for?

Some of them are: Paint (Use of suspension) Mud or muddy water, is where soil, clay, or silt particles are suspended in water. Flour suspended in water. Fog water suspended in air. Chalk powder suspended in water.

Is suspension can improve the chemical stability of a drug?

Suspension can improve chemical stability of certain drug. For example Procaine penicillin G. Drug in suspension exhibits higher rate of bioavailability than other dosage forms. Suspension can mask the unpleasant/bitter taste of drug.

Which suspension is more stable and why?

Suspension is more stable. This is because suspension does not mix with each other. The denser particles settle down at the bottom and makes the solution stable.