Table of Contents
What is formulation consideration for suspension?
The formulation of suspensions for oral administration requires consideration of the physical properties of both the therapeutic agent and the excipients required to ensure that the formulation is physically stable and suitable for administration to patients.
Why do we formulate suspension?
The reasons for the formulation of a pharmaceutical suspension: — when the drug is insoluble in the delivery vehicle. –To mask the bitter taste of the drug. –To increase drug stability.
What are the qualities of ideal suspension?
Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015
What is the advantage of independent suspension?
Independent suspension typically offers better ride quality and handling characteristics, due to lower unsprung weight and the ability of each wheel to address the road undisturbed by activities of the other wheel on the vehicle.
What are 5 examples of suspension?
Examples of Suspension Muddy water. Milk of magnesia. Sand particles suspended in water. Flour in water. Slaked lime for whitewashing. Paints in which dyes are suspended in turpentine oil.
What is the best type of suspension?
Multi-link and dual wishbone systems are the holy grail of suspension designs, allowing engineers to achieve agile handling without compromising ride quality.
How do you make flocculated suspension?
Electrolyte and ionic surfactant can be used as flocculating agents to produce a flocculated suspension. suspension prepared without flocculating agent is a deflocculated one. The physical stability of the suspension is assist by determining the sedimentation volume or degree of flocculation.
What is pharmaceutical suspension?
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. The particle diameter in a suspension is usually greater than 0.5 µm. Suspensions are an important class of pharmaceutical dosage forms.
What are the different types of suspension?
8 Types of Car Suspensions Multi-Link Suspension. Rigid Axle Suspension. Macpherson Suspension. Double Wishbone Suspension. Independent Suspension. Rigid suspension – Leaf Spring. Trailing Arm Suspension. Air Suspension.
How do I know if suspension is broken?
Here are signs your suspension is damaged. Super Bumpy Ride. If you feel as if you’re driving a vehicle with square wheels, your suspension could have some damage. Unstable Vehicle Body. Sinking Vehicle Frame. Uneven Tire Wear. Oil On Your Shocks. Bounce Test.
What is suspension theory?
A suspension is a disperse system in which solid, vehicle-insoluble particles (internal phase) are uniformly suspended by mechanical agitation and formulation design throughout the liquid vehicle (external phase). This dosage form is used for providing a liquid dosage form for insoluble drugs.
How many types of suspension are there in pharmacy?
Based on the route of administration, suspensions can be classified as oral, topical, ophthalmic, otic, or nasal suspensions. Each of these present unique challenges and requirements in terms of desired quality attributes.
How do you evaluate suspension?
Prepared suspension were evaluated by studying different parameters like pH, sedimentation volume, redispersibility, Flow rate (F), viscosity, degree of flocculation, effect of temperature etc.
What are the common problems in suspension?
Here are some common signs of suspension problems. Pulling to one side when driving. Feeling every bump. One corner sits low. Diving, rolling and/or squatting. Difficulty when steering.
What are the advantages of suspension?
The following advantages can be obtained by formulating API as a suspension dosage form. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Pharmaceutical suspensions may be formulated to mask the unpleasant/ bitter taste of drug.
What is a suspension example?
Ans: Common examples of suspension include the mixture of chalk and water, muddy water, the mixture of flour and water, a mixture of dust particles and air, fog, milk of magnesia, etc. In it, particles of the solute do not dissolve in the solution and are rather suspended.
Is suspension expensive to fix?
You need to look at the cost to repair or replace the suspension, plus the labor cost that will be associated with taking your car to an auto mechanic. The average cost of a suspension repair is between $1,000-$5,000.
Why are some drugs suspended?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
What are the suspending agents?
A suspending agent is a liquid in which a solid substance can be held in suspension. The drug is held in the suspension by a suspending agent, and does not settle at the bottom. If the tablet is dissolved in a suspending agent, this will help suspend any insoluble components in the liquid.
What are signs of suspension problems?
Suspension Warning Signs Continued bouncing after hitting bumps or a dipping when braking. A drifting or pulling to one side when turning corners. One side of the parked car sitting lower than the other side. Difficult steering. Unusually bumpy rides.
What are 3 types of suspension?
There are three basic types of suspension components: linkages, springs, and shock absorbers.
What are the two types of suspension?
There are two general classifications of suspension systems known to date; dependent and independent.
What are the disadvantages of pharmacy?
Cons of being a pharmacist The educational requirements are extensive. The education is expensive. You may need to stand for long periods. The work can be stressful. The environment can be hectic with great responsibility. You may need to work off-hours, weekends, and holidays.
What is diffusible suspension?
Suspension containing diffusible substances • They contain easily dispersible solids • They are light and easily wettable substances • Readily mixed with water and on shaking diffuse evenly throughout the liquid long enough to ensure even distribution and a dose to be measured 9.
What are disadvantages of suspension?
Suspensions also possess some disadvantages relative to other dosage forms. The primary disadvantage is their physical instability; i.e., that they tend to settle over time leading to a lack of uniformity of dose.
