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Pharmaceutical suspensions are liquid dosage forms containing finely divided insoluble materials (the suspensoid) distributed somewhat uniformly throughout the suspending medium (suspending vehicle) in which the drug exhibits a minimum degree of solubility.
What are suspensions in pharmacy?
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. In addition, when compared to solution dosage forms, relatively higher concentration of drugs can be incorporated into suspension products.
Why are drugs formulated as suspensions?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
Is milk a suspension?
Milk is a colloid, with tiny globs of butterfat suspended throughout the liquid. suspension A mixture in which particles are dispersed throughout the bulk of a fluid.
How do you use suspension drugs?
Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon. For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Which suspending agent is used in the formulation of suspension?
The most common suspending agents are aqueous biological polymers, including methylcellulose (MC), sodium carboxymethylcellulose (CMC), and hydroxypropylmethylcellulose (HPMC). A range of viscosities of suspending agents is available with different molecular weights.
What are 3 types of suspension?
There are three basic types of suspension components: linkages, springs, and shock absorbers.
Why do we make suspension?
Suspension can improve chemical stability of certain drug. For example Procaine penicillin G. Drug in suspension exhibits higher rate of bioavailability than other dosage forms.
What are some good things about suspension bridge?
Pros of a Suspension Bridge
- It can span over long distances. Suspension bridges can span anywhere between 2,000 to 13,000 feet, which is farther than any type of bridge can accommodate.
- It is inexpensive to build.
- It is easy to maintain.
- It is incredibly versatile.
- It is aesthetically pleasing.
What are 5 examples of suspension?
Examples of Suspension
- Muddy water.
- Milk of magnesia.
- Sand particles suspended in water.
- Flour in water.
- Slaked lime for whitewashing.
- Paints in which dyes are suspended in turpentine oil.
How do you evaluate suspension?
Prepared suspension were evaluated by studying different parameters like pH, sedimentation volume, redispersibility, Flow rate (F), viscosity, degree of flocculation, effect of temperature etc.
What are the 3 uses of suspensions?
Some of them are: Flour suspended in water. Fog water suspended in air. Chalk powder suspended in water. Dust particles suspended in air.
How do you create a suspension?
A suspension happens when a note from a chord is held over (or repeated) in the following chord, creating a brief dissonance with the bass. The held note then falls to a note belonging to the second chord.
What is suspension advantages and disadvantages?
Advantages & Disadvantages: Advantages: • Can improve chemical stability of certain drugs. • Higher rate of bioavailability, as order of bioavailabilty is: Solution > Suspensions > Capsules > Compressed tablets Dias advantages: • Physical stability, sedimentation and compaction. • Bulky, handling reqire care.
What properties should a well formulated suspension possess?
A good suspension should have well developed thixotropy. At rest the solution is sufficient viscous to prevent sedimentation and thus aggregation or caking of the particles. When agitation is applied the viscosity is reduced and provide good flow characteristic from the mouth of bottle.
What is the advantage of suspension?
1. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Although low-solubility therapeutic agents may be solubilised and therefore administered as a solution, the volume of the solvent required to perform this may be large.
What is an ideal suspension?
An ideal suspension must possess the following properties:- 1 It should settle slowly and should be readily re-dispersed on gentle shaking of the container. 2 The particle size of the suspension remains fairly constant throughout its long period of undisturbed standing .
What are suspending agents?
: a substance (such as carrageenan, xanthan gum, or cellulose ether) that is added to fluids to promote particle suspension or dispersion and reduce sedimentation All these drinks can contain preservatives, and drinks other than juices can contain additives to colour, flavour and sweeten.
How do you make flocculated suspension?
Preparation of various types suspensions and determination of their sedimentation parameters
- Electrolyte and ionic surfactant can be used as flocculating agents to produce a flocculated suspension.
- The physical stability of the suspension is assist by determining the sedimentation volume or degree of flocculation.
What should be done before using suspension?
To be effective, a suspension must be shaken before administered.
How do you administer oral suspension?
Medication Syringe Instructions
- Fill the syringe with the prescribed dosage of medicine.
- Hold the syringe upright and gently tap the air bubbles toward the end.
- Push the plunger gently to force the air out of the end.
- Check that you have the correct amount of medication left in the syringe.
What are the disadvantages of suspension?
v) Drug in suspension exhibits a higher rate of bioavailability compared to the same drug of equivalent dose formulated in tablets or capsules. This is due to larger surface area and high dissolution, e.g., antacid suspension. 1. Sedimentation of solids occasionally gives poor form of product.
What are the example of suspending agents?
The most common suspending agents are aqueous biological polymers, including methylcellulose (MC), sodium carboxymethylcellulose (CMC), and hydroxypropylmethylcellulose (HPMC).
How do you make suspension drugs?
Gently shake the bottle to loosen the powder. Open the cap. Carefully add cool boiled water to about half the height of the final marking on the bottle.
Where can we use suspension?
Examples of suspension in a Sentence His record shows several suspensions from school. He’s under suspension for breaking the rules. a suspension of the rules She was punished by suspension of her driver’s license.
What is a suspension simple definition?
In a suspension, very small pieces of solid are mixed in a liquid but do not dissolve. If left still, the solid pieces will separate from the liquid and either fall to the bottom or rise to the top. Sand in water and flour in water are examples of suspensions. If a liquid is suspended in a gas it is an aerosol.
How many types of suspension are there in pharmacy?
Based on the route of administration, suspensions can be classified as oral, topical, ophthalmic, otic, or nasal suspensions. Each of these present unique challenges and requirements in terms of desired quality attributes. These are briefly described as follows: 1.
What is a suspension example?
Ans: Common examples of suspension include the mixture of chalk and water, muddy water, the mixture of flour and water, a mixture of dust particles and air, fog, milk of magnesia, etc. In it, particles of the solute do not dissolve in the solution and are rather suspended.
