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Pharmaceutical suspensions are usually prepared either by direct incorporation/ dispersion method or by precipitation method. Suspensions can also be formulated using controlled flocculation method.
What are the methods of preparation of suspension?
Methods For Formulation of Suspension 1-Precipitation method: Three precipitation methods are used: Organic solvent precipitation: • Water insoluble drugs can be precipitated by dissolving them in water- miscible organic solvent and then adding organic phase to distilled water under standard conditions.
What is suspension in pharmaceutical preparation?
A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. In addition, when compared to solution dosage forms, relatively higher concentration of drugs can be incorporated into suspension products.
Which one of properties is applicable to suspension?
The properties of suspension are listed below. A suspension is a heterogeneous solution in which, while standing, several particles move out of the mixture. In a suspension, the volume of the solvent particles is quite high. It has a length of more than 100 mm.
What is syrup in pharmacy?
A syrup is a concentrated or nearly saturated solution of sucrose in water. A simple syrup contains only sucrose and purified water (e.g. Syrup USP). Syrups containing pleasantly flavored substances are known as flavoring syrups (e.g. Cherry Syrup, Acacia Syrup, etc.).
What is special about a suspension liquid medication?
In an elixir, the active ingredients are mixed with a liquid, usually a kind of syrup or alcohol, in which they can dissolve. In a suspension, the medicine is mixed with a liquid, usually water, in which it cannot dissolve and therefore remains intact in the form of small particles.
What is the difference between suspension and oral suspension?
Oral suspensions are very similar to solutions but the drug particles do not completely dissolve into the solvent. They are, instead, “suspended” in the medium of liquid (1) very much like dust particles suspend in the air. Another commonly seen suspension is Paracetamol.
Why are some drugs suspended?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
What are signs of suspension problems?
Suspension Warning Signs
- Continued bouncing after hitting bumps or a dipping when braking.
- A drifting or pulling to one side when turning corners.
- One side of the parked car sitting lower than the other side.
- Difficult steering.
- Unusually bumpy rides.
What is a suspension drug?
A suspension is a liquid with small pieces of drug. The drug is not complete dissolved in the solution. Whenever you take a suspension, you should always shake (or stir) it so that you receive the right amount of drug every time you take it.
What are 3 types of suspension?
There are three basic types of suspension components: linkages, springs, and shock absorbers.
What is suspension formulation?
Pharmaceutical suspensions are liquid dosage forms containing finely divided insoluble materials (the suspensoid) distributed somewhat uniformly throughout the suspending medium (suspending vehicle) in which the drug exhibits a minimum degree of solubility.
What are the advantages of suspension?
The following advantages can be obtained by formulating API as a suspension dosage form.
- Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility.
- Pharmaceutical suspensions may be formulated to mask the unpleasant/ bitter taste of drug.
What are 5 examples of suspension?
Examples of Suspension
- Muddy water.
- Milk of magnesia.
- Sand particles suspended in water.
- Flour in water.
- Slaked lime for whitewashing.
- Paints in which dyes are suspended in turpentine oil.
How many types of suspension are there in pharmacy?
Based on the route of administration, suspensions can be classified as oral, topical, ophthalmic, otic, or nasal suspensions. Each of these present unique challenges and requirements in terms of desired quality attributes. These are briefly described as follows: 1.
What are the two types of suspension?
There are two general classifications of suspension systems known to date; dependent and independent. A dependent suspension system connotes that there is a beam or axle that connects the left wheel to the right so they work in tandem with each other.
What are the basic properties of a good suspension?
Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015
What are the disadvantages of suspension?
v) Drug in suspension exhibits a higher rate of bioavailability compared to the same drug of equivalent dose formulated in tablets or capsules. This is due to larger surface area and high dissolution, e.g., antacid suspension. 1. Sedimentation of solids occasionally gives poor form of product.
What are the 4 types of suspension?
Car Suspension 101: Understanding the Four Types of Spring Systems
- Leaf Springs. Leaf springs are made up of a cascading set of blades held together by a U-bolt.
- Coil Springs. If you know what a Slinky is, then you know what a coil spring looks like.
- Torsion Bars.
- Air Springs.
What are ingredients used in suspension?
The possible types of excipients commonly used in the formulation of pharmaceutical suspensions include:
- 1 1. Solvents/ Vehicle.
- 2 2. Co-solvent.
- 3 3. Buffering agents.
- 4 4. Preservatives.
- 5 5. Antioxidants.
- 6 6. Wetting agents/ surfactants.
- 7 7. Anti-foaming agents.
Why do we make suspension?
Suspensions are the biphasic liquid dosage form of medicaments in which the finely divided solid particles. If patient has a difficulty of swallowing solid dosage forms (a need for oral liquid dosage form). Faster rate of dissolution and oral absorption than solid dosage forms, yet slower than solutions.
What are Class 9 suspension properties?
Properties of Suspension The particles of a suspension can be seen easily. The particles of a suspension do not pass through a filter paper. So a suspension can be separated by filtration. The suspension is unstable.
Can you give other examples of common suspension?
Give some examples of suspension. Ans: Common examples of suspension include the mixture of chalk and water, muddy water, the mixture of flour and water, a mixture of dust particles and air, fog, milk of magnesia, etc. In it, particles of the solute do not dissolve in the solution and are rather suspended.
What is the best type of suspension?
Multi-link and dual wishbone systems are the holy grail of suspension designs, allowing engineers to achieve agile handling without compromising ride quality.
How does a suspension appear?
An suspension is when you mix a liquid and a solid, where the solid does not dissolve in the liquid. If this appears then you have an suspension. The suspension will appear as small “grain” looking object floating in the solution.
