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A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. In addition, when compared to solution dosage forms, relatively higher concentration of drugs can be incorporated into suspension products.
What is meant by suspension in pharmacy?
Definition. ➢ A Pharmaceutical suspension is a coarse dispersion in which internal phase (therapeutically active ingredient)is dispersed uniformly throughout the external phase.
How many types of suspension are there in pharmacy?
Based on the route of administration, suspensions can be classified as oral, topical, ophthalmic, otic, or nasal suspensions. Each of these present unique challenges and requirements in terms of desired quality attributes.
Why are suspensions used in medicine?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
Which is desirable suspension?
Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015
What are the suspending agents?
A suspending agent is a liquid in which a solid substance can be held in suspension. The drug is held in the suspension by a suspending agent, and does not settle at the bottom. A suspending agent is a liquid in which a solid substance can be held in suspension.
What is the advantage of independent suspension?
Independent suspension typically offers better ride quality and handling characteristics, due to lower unsprung weight and the ability of each wheel to address the road undisturbed by activities of the other wheel on the vehicle.
What is the difference between suspension and oral suspension?
Unlike pharmaceutical syrup, oral solution is relatively similar only that the drug particles do not dissolve into solvent completely. Finally, the solution will form two distinct layers where the top layer is less concentrated than the bottom one. For young children, most of the suspension used is liquid antibiotics.
What are ingredients used in suspension?
The possible types of excipients commonly used in the formulation of pharmaceutical suspensions include: 1 1. Solvents/ Vehicle. 2 2. Co-solvent. 3 3. Buffering agents. 4 4. Preservatives. 5 5. Antioxidants. 6 6. Wetting agents/ surfactants. 7 7. Anti-foaming agents.
What is a suspension example?
Ans: Common examples of suspension include the mixture of chalk and water, muddy water, the mixture of flour and water, a mixture of dust particles and air, fog, milk of magnesia, etc. In it, particles of the solute do not dissolve in the solution and are rather suspended.
What are signs of suspension problems?
Suspension Warning Signs Continued bouncing after hitting bumps or a dipping when braking. A drifting or pulling to one side when turning corners. One side of the parked car sitting lower than the other side. Difficult steering. Unusually bumpy rides.
What are the 4 types of suspension?
To avoid various damage to the car, you can do spooring regularly. Multi-Link Suspension. Rigid Axle Suspension. Macpherson Suspension. Double Wishbone Suspension. Independent Suspension. Rigid suspension – Leaf Spring. Trailing Arm Suspension. Air Suspension.
How many types of suspension are there?
There are three basic types of suspension components: linkages, springs, and shock absorbers.
How do you make flocculated suspension?
Electrolyte and ionic surfactant can be used as flocculating agents to produce a flocculated suspension. suspension prepared without flocculating agent is a deflocculated one. The physical stability of the suspension is assist by determining the sedimentation volume or degree of flocculation.
What are the common problems in suspension?
Here are some common signs of suspension problems. Pulling to one side when driving. Feeling every bump. One corner sits low. Diving, rolling and/or squatting. Difficulty when steering.
What is an example of a suspension drug?
Examples of a few of the oral suspensions in which a specific and well defined particle size specification for the drug substance is important include phenytoin suspension, carbamazepine suspension, trimethoprim and sulfamethoxazole suspension, and hydrocortisone suspension.
How do you make an antibiotic suspension?
In order to prepare antibiotic suspension, 302 (75.5 %) used boiled then cooled water, 192 (48.4 %) of mothers used a syringe to measure the needed amount of water, and 304 (76.6 %) added water in two steps, 392 (98.0 %) of mothers claimed that they shook the suspension bottle before use.
Why are suspensions prepared?
The external phase (suspending medium) is generally aqueous in some instance, may be an organic or oily liquid for non-oral use. 7. Advantages And Disadvantages: Advantages: • Suspension can improve chemical stability of certain drug. Drug in suspension exhibits higher rate of bioavailability than other dosage forms.
What are the two types of suspension?
There are two general classifications of suspension systems known to date; dependent and independent.
How do you make a suspension?
METHOD OF PREPARATION OF SUSPENSION PRECIPITATION METHOD: It involves an insoluble solvent that is added to the drug to make it precipitate out from soluble portion. Usually the solvents are organic & the thpe of precipitation depends on the type of solvent used, the amount of solvent used & the rate of drying.
What are suspensions 10 examples?
Examples of Suspension Muddy water. Milk of magnesia. Sand particles suspended in water. Flour in water. Slaked lime for whitewashing. Paints in which dyes are suspended in turpentine oil.
Why are suspensions better than solutions?
Particles in a suspension tend to travel through the medium and undergo sedimentation with time. Due to the large sizes of particles, they can be easily separated by filtration. Suspensions are cloudy, unlike solutions due to bigger particle size. Light is scattered or reflected by these particles.
What are disadvantages of suspension?
Suspensions also possess some disadvantages relative to other dosage forms. The primary disadvantage is their physical instability; i.e., that they tend to settle over time leading to a lack of uniformity of dose.
What is called suspension?
A suspension is a heterogeneous mixture of a finely distributed solid in a liquid. The solid is not dissolved in the liquid, as is the case with a mixture of salt and water. Suspension. Examples of Suspensions.
What are the advantages of suspension?
The following advantages can be obtained by formulating API as a suspension dosage form. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Pharmaceutical suspensions may be formulated to mask the unpleasant/ bitter taste of drug.
Is syrup and suspension same?
The difference between syrup and suspension is that syrup is a solution consisting of sugar that is readily dissolvable in other solvents, while the suspension is a biphasic liquid system containing insoluble solute particles in the liquid medium.
