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Suspensions are unstable from a thermodynamic point of view but can be kinetically stable over a longer period of time, which in turn can determine a suspension’s shelf life. This time span needs to be measured in order to provide accurate information to the consumer and ensure the best product quality.
Are suspensions stable class 9?
Suspensions are heterogeneous mixture of two or more substances. Particles of solute do not dissolve in solvent rather they remain suspended in bulk throughout. Therefore, suspension is not stable. The particles of suspension can be separated through the process of filtration.
How do I stabilize my suspension?
Stabilizing a suspension There are various routes that can be undertaken to improve suspension stability – for example, stabilization can be achieved by: preventing coagulation through inter-particle repulsion. slowing down sedimentation by increasing the viscosity of the continuous phase.
What is difference between solution and suspension?
Solutions are mixtures that are homogeneous while suspensions are mixtures that are heterogeneous. The particles of a solution are at the ion or molecular level and cannot be seen by the naked eye while the particles of a suspension can be seen by the naked eye.
What are the qualities of ideal suspension?
Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015
What are the stability problem of suspension?
Because suspensions are thermodynamically unstable system, physical stability of suspensions becomes as important as the chemical and biological stability. Physical stability of suspensions is the condition in which the particles do not aggregate and in which they remain uniformly distributed throughout the dispersion.
Which is most stable suspension?
Suspension is more stable. This is because suspension does not mix with each other. The denser particles settle down at the bottom and makes the solution stable.
Why are suspending agents used?
They help in lowering the sedimentation rate of particles in suspension. They usually prevent caking at the base of an suspension . It could be resuspendend by agitation. It is majorly used as an excipients to help active pharmaceutical ingredients stay suspended in formulation.
Which is more stable true solution or suspension?
Complete answer: True solutions are more stable than suspension. True solutions remain stable as the particles are almost uniform in size and do not settle down if left untouched for a given time interval.
Do suspensions show Tyndall effect?
Tyndall’s effect is the appearance of light scattering on the particles of colloidal dimensions. Because of the small particle size, the solutions do not show Tyndall’s effect. Suspensions have larger particles than colloids and thats why they show the Tyndall effect.
Why suspension is called unstable?
Suspensions are unstable from the thermodynamic point of view; however, they can be kinetically stable over a large period of time, which determines their shelf life.
What are problems associated with suspension?
Suspension problems can include the following. Steering pull to the left or right. Tracking or drifting problems can be caused by worn parts, fluid leaks, or even steering system problems. Bumpy ride. Noises that appear when a vehicle goes over a bump may be related to broken, loose, or worn suspension parts.
Why rheology is important for suspension stability?
Rheologic consideration is of great importance in the study of the stability of pharmaceutical suspensions. This is because the viscosity of a suspension can modify the sedimentation rate.
Which is more stable true solution or colloid?
colloidal solution is the more stable true solution or suspension.
Is suspension can improve the chemical stability of a drug?
Suspension can improve chemical stability of certain drug. ➢Drug in suspension exhibits higher rate of bioavailability than other dosage forms.
How do I know if my suspension is stable?
Suspension stability can be theoretically estimated prior to the beginning of the formulating process based on the solid phase particle size, liquid phase density, and viscosity. Stokes equation can be used to predict suspension stability in order to save time and resources.
Why suspension is unstable Class 9?
Suspension is a heterogeneous mixture. The particles of a suspension can be seen by the naked eye. The particles of a suspension scatter a beam of light passing through it and make its path visible. The solute particles settle down when a suspension is left undisturbed, that is, a suspension is unstable.
What is the advantage of passing a suspension through a homogenizer?
What Should You Look for in a Homogenizer for Colloidal Suspensions. Unlike a colloidal mill, a homogenizer is better able to reduce particle size so that resulting mixtures are much more consistent and uniform.
Which agent is used for stability of suspension?
Xanthan gum in drug delivery applications XG is widely used as a suspending agent and stabilizer in suspension due to its safety properties in food and drug applications. Moreover, it is soluble in water and can provide sufficient viscosity in low concentration.
What are the types of suspending agents?
Suspending agents are grouped into three classes: synthetic, semi synthetic and the natural polysaccharides, in which class acacia, tragacanth and starch belong to the latter class (Mbang et al., 2004; Mahmud et al., 2010).
Which is more stable Fe2+ or Fe3+?
Fe3+ is more stable than Fe2+. In Fe3+ ions, there are five 3d half-filled orbitals and is more symmetrical than Fe2+. Whereas in Fe2+ ion there are four 3d half-filled orbitals and one orbital is filled.
What is used for increasing the stability of suspension?
There are some useful methods to improve the physical stability of a suspension, such as decreasing the salt concentration, addition of additives to regulate the osmolarity, as well as changes in excipient concentrations, unit operations in the process, origin and synthesis of the drug substance, polymorphic behavior
What is the particle range of suspension?
Difference between Colloid and Suspension Suspension Colloid It is a form of the heterogeneous solution It is a form of a homogeneous solution Particle size greater than 1000 nm Particle size range from 1 and 1000 nm Particles settle down well Particles do not separate.
How do you overcome stability problems of suspension?
Increasing the viscosity – increasing the viscosity of the continuous phase can lead to the stability of suspensions. This is so because the rate of sedimentation can be reduced by increase in viscosity. Viscosity increase is brought about by addition of thickening agents to the external phase.
