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A deflocculated suspension is a suspension in which no flocculation has taken place. Hence, there are no floccules or other aggregates. Here, single colloid particles act as individual particles. When sedimentation occurs, these single particles settle.
What is flocculated and non flocculated suspension?
The suspension are said to be flocculated ,when the individual particles are in contact with each other and form a network like structure . Whereas in case of non-flocculated suspensions,the individual particles exists as a separate entity. In Non-flocculated suspensions- Particles exist as separate entities.
What is the difference between flocculated and Deflocculated?
The key difference between flocculation and deflocculation is that flocculation is the formation of flocs by the clumping of fine particles, whereas deflocculation is the dispersion of flocs to form a stable colloid. Flocculation refers to the formation of clumps from fine particles in a colloid.
What do you mean by flocculated suspension?
Flocculation refers to the formation of a loose aggregation of discrete particles held together in a network like structure by physical adsorption of macromolecules when the longer-range van der Walls forces of attraction exceed the shorter-range forces of repulsion. Such a suspension is called flocculated suspension.
Which suspension is good flocculated or Deflocculated?
INTRODUCTION Flocculated suspension Deflocculated suspension Sediment is loosely packed and does not form a hard cake. Sediment is tightly packed and forms a hard cake. The supernatant is clear. The supernatant is hazy. Floccules stick to the sides of the bottle. Particles do not stick to the sides of the bottle.
What are the advantages of suspension?
The following advantages can be obtained by formulating API as a suspension dosage form. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Pharmaceutical suspensions may be formulated to mask the unpleasant/ bitter taste of drug.
What is difference between emulsion and suspension?
Mixtures can be of many types like a solution, suspension and colloids. A mixture can be classified into two types, homogeneous mixture and heterogeneous mixture.Difference between Suspension and Emulsion. Suspension Emulsion Solid particles are dispersed in any medium, that can be solid, gas or liquid Both dispersed phase and the dispersion medium are liquid.
What are the suspending agents?
A suspending agent is a liquid in which a solid substance can be held in suspension. If the tablet is dissolved in a suspending agent, this will help suspend any insoluble components in the liquid. A suspending agent is a liquid in which a solid substance can be held in suspension.
Is Redisperse difficult?
In a deflocculated system the dispersed particles remain as discrete units. Because the rate of sedimentation depends on the size of each unit, settling will be slow. The slow rate of settling prevents the entrapment of liquid within the sediment, which thus becomes compacted and can be very difficult to redisperse.
What is a suspension in pharmacy?
Definition. ➢ A Pharmaceutical suspension is a coarse dispersion in which internal phase (therapeutically active ingredient)is dispersed uniformly throughout the external phase.
What is stability of suspension?
Suspension stability can be theoretically estimated prior to the beginning of the formulating process based on the solid phase particle size, liquid phase density, and viscosity. In order to prevent formation of the solid sediment, controlled flocculation of the suspended bismuth subnitrate particles is recommended.
What factors affect suspension?
Factors affecting rheology of a suspension Dispersed phase content. The content of the dispersed phase φ is the most important physical parameter that affects the viscosity of dispersions. Particle shape. Particle size and size distribution. Temperature.
What is meaning of Flocculated?
[ flŏk′yə-lā′shən ] n. The process of becoming flocculent. Precipitation from solution in the form of fleecy masses.
Why suspended particles become flocculated in a suspension?
Answer: Ionic surfactants cause flocculation by neutralizing the charge on each particle, resulting into a flocculated suspension. When the surfactants reduce the interfacial tension, the liquid becomes capable of displacing the adsorbed film of air from the surface of solid drug particle and facilitating wetting.
What are the disadvantages of pharmacy?
10 Cons Of Being a Pharmacist Extensive education requirements. Costly to study pharmacy. You are responsible for the efficacy and quality of medications. Long shift-hours. Increased competition. Handling problems from patients and medical professionals. There is no room for error. Few job advancement opportunities.
What are the disadvantages of independent suspension?
A marked disadvantage of the independent suspension system is the weight it places on the vehicle. The result of the heavier suspension coupled with independent wheel movements can result in a condition known as “under steer” whereby the car’s trajectory during turns does not match up with the path the driver intends.
Why are suspensions better than solutions?
Particles in a suspension tend to travel through the medium and undergo sedimentation with time. Due to the large sizes of particles, they can be easily separated by filtration. Suspensions are cloudy, unlike solutions due to bigger particle size. Light is scattered or reflected by these particles.
Is milk an emulsion or suspension?
Milk is an emulsion in which fat globules are suspended in water. Milk is an oil in water type of emulsion because fat globules in milk are suspended in water. Thus, milk is an emulsion of oil in water type. Thus, milk is an emulsion.
Is oil and water an emulsion or suspension?
Emulsions are an example of colloids composed of tiny particles suspended in another immiscible (unmixable) material. An emulsion is a suspension of two liquids that usually do not mix together. These liquids that do not mix are said to be immiscible. An example would be oil and water.
What is the difference between syrup and suspension?
While syrup is a pharmaceutical solution that completely dissolves into its solvent, with the distribution of drugs within the solution being even, a suspension is drug mixture whereby the drug particles do not fully dissolve into the solvent.
What are 5 examples of suspension?
Examples of Suspension Muddy water. Milk of magnesia. Sand particles suspended in water. Flour in water. Slaked lime for whitewashing. Paints in which dyes are suspended in turpentine oil.
Why are suspending agents used?
They help in lowering the sedimentation rate of particles in suspension. They usually prevent caking at the base of an suspension . It could be resuspendend by agitation. It is majorly used as an excipients to help active pharmaceutical ingredients stay suspended in formulation.
