Table of Contents
What are flocculated suspensions?
Flocculated suspensions Flocculation refers to the formation of a loose aggregation of discrete particles held together in a network like structure by physical adsorption of macromolecules when the longer-range van der Walls forces of attraction exceed the shorter-range forces of repulsion.
Why flocs are required for suspension?
In this way, particle aggregates (flocs) are formed that are very much larger than the original (primary) particles so that they can be more easily separated by physical methods. In these cases, the suspension needs to be destabilized so that repulsion between particles is reduced and attachment becomes possible.
What is difference between emulsion and suspension?
Mixtures can be of many types like a solution, suspension and colloids. A mixture can be classified into two types, homogeneous mixture and heterogeneous mixture.Difference between Suspension and Emulsion. Suspension Emulsion Solid particles are dispersed in any medium, that can be solid, gas or liquid Both dispersed phase and the dispersion medium are liquid.
What do you mean by Flocculated and Deflocculated suspension?
Flocculated Suspension: A flocculated suspension is a suspension in which particles have undergone flocculation. Deflocculated Suspension: A deflocculated suspension is a suspension where no flocculation has taken place.
What are the features of flocculated suspension?
INTRODUCTION Flocculated suspension Deflocculated suspension The rate of sedimentation is high. The rate of sedimentation is slow. Sediment is easy to re-disperse. Sediment is difficult to re-disperse. Sediment is loosely packed and does not form a hard cake. Sediment is tightly packed and forms a hard cake.
What are the disadvantages of independent suspension?
A marked disadvantage of the independent suspension system is the weight it places on the vehicle. The result of the heavier suspension coupled with independent wheel movements can result in a condition known as “under steer” whereby the car’s trajectory during turns does not match up with the path the driver intends.
What are the advantages of suspension?
The following advantages can be obtained by formulating API as a suspension dosage form. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Pharmaceutical suspensions may be formulated to mask the unpleasant/ bitter taste of drug.
What are the suspending agents?
A suspending agent is a liquid in which a solid substance can be held in suspension. If the tablet is dissolved in a suspending agent, this will help suspend any insoluble components in the liquid. A suspending agent is a liquid in which a solid substance can be held in suspension.
How Deflocculation is different from flocculation?
The key difference between flocculation and deflocculation is that flocculation is the formation of flocs by the clumping of fine particles, whereas deflocculation is the dispersion of flocs to form a stable colloid. These clumps are called flocs. May 24, 2019
What is meaning of Flocculated?
The process by which individual particles of clay aggregate into clotlike masses or precipitate into small lumps. Flocculation occurs as a result of a chemical reaction between the clay particles and another substance, usually salt water.
What is stability of suspension?
Suspension stability can be theoretically estimated prior to the beginning of the formulating process based on the solid phase particle size, liquid phase density, and viscosity. In order to prevent formation of the solid sediment, controlled flocculation of the suspended bismuth subnitrate particles is recommended.
What is the advantage of passing a suspension through a homogenizer?
What Should You Look for in a Homogenizer for Colloidal Suspensions. Unlike a colloidal mill, a homogenizer is better able to reduce particle size so that resulting mixtures are much more consistent and uniform.
What are the difference between flocculated and non flocculated suspension?
The suspension are said to be flocculated ,when the individual particles are in contact with each other and form a network like structure . Whereas in case of non-flocculated suspensions,the individual particles exists as a separate entity. In Non-flocculated suspensions- Particles exist as separate entities.
What are the methods for improving the stability of suspension?
There are some useful methods to improve the physical stability of a suspension, such as decreasing the salt concentration, addition of additives to regulate the osmolarity, as well as changes in excipient concentrations, unit operations in the process, origin and synthesis of the drug substance, polymorphic behavior
What does suspension mean in pharmacy?
In a suspension, the medicine is mixed with a liquid, usually water, in which it cannot dissolve and therefore remains intact in the form of small particles. Elixirs are typically more concentrated, so remember to always read the dosage instructions on the bottle before giving your child any medication.
How do I stop my suspension from caking?
Caking may be prevented by designing suspensions with a structured network that supports the particles and keeps them from entering a close-packed array. The network may consist of suspending agent (structured vehicle), the particles themselves (flocculated), or a combination of the two.
How do you make flocculated suspension?
Electrolyte and ionic surfactant can be used as flocculating agents to produce a flocculated suspension. suspension prepared without flocculating agent is a deflocculated one. The physical stability of the suspension is assist by determining the sedimentation volume or degree of flocculation.
What are the disadvantages of suspension?
Suspensions also possess some disadvantages relative to other dosage forms. The primary disadvantage is their physical instability; i.e., that they tend to settle over time leading to a lack of uniformity of dose.
What are the 4 types of suspension?
To avoid various damage to the car, you can do spooring regularly. Multi-Link Suspension. Rigid Axle Suspension. Macpherson Suspension. Double Wishbone Suspension. Independent Suspension. Rigid suspension – Leaf Spring. Trailing Arm Suspension. Air Suspension.
What are the disadvantages of pharmacy?
10 Cons Of Being a Pharmacist Extensive education requirements. Costly to study pharmacy. You are responsible for the efficacy and quality of medications. Long shift-hours. Increased competition. Handling problems from patients and medical professionals. There is no room for error. Few job advancement opportunities.
What are signs of suspension problems?
Suspension Warning Signs Continued bouncing after hitting bumps or a dipping when braking. A drifting or pulling to one side when turning corners. One side of the parked car sitting lower than the other side. Difficult steering. Unusually bumpy rides.
What are the qualities of ideal suspension?
Desirable properties of suspensions are that they should have good organoleptic properties, suspensions should possess good pourability leading to ease of removal of dose from container, the particle size distribution should be uniform, there should be ease of re dispersion of settled solid particles, they should be Dec 8, 2015
Which type of suspension is best?
Multi-link and dual wishbone systems are the holy grail of suspension designs, allowing engineers to achieve agile handling without compromising ride quality.
What are 3 types of suspension?
There are three basic types of suspension components: linkages, springs, and shock absorbers.
